Comparison of facemask and mouthpiece interfaces for multiple breath washout measurements

Correcting for tissue nitrogen excretion in multiple breath washout measurements

Nitrogen excreted from body tissues impacts the calculation of multiple breath nitrogen washout (MBWN2) outcomes. The aim of this study was to determine the effect of tissue N2 on MBWN2 outcomes in both healthy subjects and patients with CF and to assess whether it is possible to correct for tissue N2. The contribution of tissue N2 to MBWN2 outcomes was estimated by comparing MBWN2-derived func...

Equipment for multiple breath washout.

5 Demeo DL, Campbell EJ, Barker AF, et al. IL10 polymorphisms are associated with airflow obstruction in severe alpha1-antitrypsin deficiency. We read with interest the article ''Paediatrics in Berlin'' [1] in a recent issue of the European Respiratory Journal, which sum-marised the paediatric topics of the European Respiratory Society's Annual Congress in Berlin. In this article, inert gas mul...

Multiple-breath washout measurements can be significantly shortened in children.

Multiple-breath washout (MBW)-derived lung clearance index (LCI) is a sensitive measure of ventilation inhomogeneity in patients with cystic fibrosis (CF), but LCI measurement is time consuming. We systematically assessed ways to shorten LCI measurements. In 68 school-aged children (44 with mild CF lung disease) three standard nitrogen (N2) MBWs were applied. We assessed repeatability and diagn...

Title: Guidelines for Inert Gas Washout Measurements for Multiple and Single Breath Tests:

Authors 1. Robinson, P.D.1,2,3 2. Latzin, P.4 3. Verbanck, S.5 4. Hall, G.L.6,7 5. Horsley, A.8 6. Gappa, M.9 7. Thamrin, C.2,4 8. Arets, H.G.M10 9. Aurora, P.3,11 10. Fuchs, S.9 11. King, G.G.2,12 12. Lum, S.3 13. Macleod, K.13 14. Paiva, M.14 15. Pillow, J.15,16 16. Ranganathan, S.17,18 17. Ratjen, F.19 18. Singer, F.4 19. Sonnappa, S.3,11 20. Stocks. J3 21. Subbarao, P.19 22. Thompson, B.20 ...

The facemask produces higher peak minute ventilation and respiratory rate measurements compared to the mouthpiece.